The ultimate approach to gaining specific insights on how to supplement based on your DNA is to take the DNA Methylation test. A DNA methylation test analyzes specific markers in your DNA to assess the methylation process, which impacts gene expression and various bodily functions. These tests, using saliva samples, can reveal genetic predispositions and potential health risks related to methylation, such as nutrient metabolism, detoxification, and neurological health.
What does a methylation test do?
- Analyzes gene variations: Methylation tests examine specific genes involved in the methylation pathway, like MTHFR and COMT, to identify variations (SNPs) that might impair their function.
- Provides insights into nutrient metabolism: The tests can reveal how well your body processes essential nutrients like folate, B12, and choline, which are crucial for methylation.
- Assesses methylation pathway activity: By analyzing DNA methylation patterns, the tests can offer insights into the overall health of your methylation cycle and its impact on various bodily functions.
- Can be used for personalized recommendations: The results can guide dietary adjustments, supplementation, and lifestyle choices to optimize methylation and improve overall health.
How are methylation tests performed?
- Sample collection: Most tests involve collecting a DNA sample from saliva (cheek swab).
- Laboratory analysis: The samples are sent to a lab for analysis, where they are checked for specific methylation patterns and five specific gene variations.
- Report generation:
- The results are compiled into a report that provides insights into your methylation status, potential risks, and personalized nutrition recommendations.
Who might benefit from a methylation test?
- Individuals with a family history of certain conditions like cardiovascular disease, neurological disorders, or mood disorders.
- Those experiencing symptoms related to methylation imbalances, such as chronic fatigue, cognitive issues, or digestive problems.
- Individuals interested in optimizing their health and well-being through personalized insights into their genetic makeup.
Test components
1. MTHFR
The MTHFR gene’s purpose is to produce the important MTHFR enzyme in the body. This enzyme is an important part of maintaining optimal health. If the MTHFR gene has a variant, folate metabolism can be negatively impacted. Improper folate metabolism is implicated in many different diseases.
2. MTR
MTR codes for the enzyme, methionine synthase (MS). MS converts homocysteine to methionine using methylated vitamin B12. variants in this gene significantly impact homocysteine metabolism, which can increase the risk for a number of chronic conditions such as cardiovascular diseases, metabolic and neurological conditions and certain cancers.
3. MTRR
The MTRR gene codes for the important enzyme, methionine synthase reductase (MSR). Methionine synthase reductase is required for the proper function of methionine synthase (see MTR). Both genes act together to convert homocysteine to methionine. variants can be involved with the development of cancers, Parkinson’s disease, depression, hypertension and many others.
4. COMT
COMT is the major gene involved in methylation. It plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others. COMT is also necessary for maintaining the proper balance of neurotransmitters with SAMe obtained from methionine. Genetic variants in COMT can result in various neurological problems and has also been associated with Autism.
5. AHCY
AHCY is the only enzyme known to convert S-Adenosylhomocysteine (AdoHcy) to homocysteine. It is crucial that AHCY immediately converts AdoHcy to homocysteine and adenine in order to maintain optimal methylation potential. Studies show a link between variants in this gene with poor methylation potential and severe myopathies, developmental delays and hypermethioninemia.
6. Homocysteine
Homocysteine is an amino acid that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative disorders.